منابع مشابه
Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection.
Infection of hepatocytes by Plasmodium falciparum sporozoites requires the host tetraspanin CD81. CD81 is also predicted to be a coreceptor, along with scavenger receptor BI (SR-BI), for hepatitis C virus. Using SR-BI-knockout, SR-BI-hypomorphic and SR-BI-transgenic primary hepatocytes, as well as specific SR-BI-blocking antibodies, we demonstrate that SR-BI significantly boosts hepatocyte perm...
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Nonalcoholic steatohepatitis is characterized by hepatic steatosis, elevated levels of circulating free fatty acids (FFA), endoplasmic reticulum (ER) stress, and hepatocyte lipoapoptosis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor 5 (DR5) is significantly elevated in patients with nonalcoholic steatohepatitis, and steatotic hepatocytes demonstrate increased s...
متن کاملSpecies-specific features of DARC, the primate receptor for Plasmodium vivax and Plasmodium knowlesi.
The DARC (Duffy antigen/receptor for chemokines) gene, also called Duffy or FY, encodes a membrane-bound chemokine receptor. Two malaria parasites, Plasmodium vivax and Plasmodium knowlesi, use DARC to trigger internalization into red blood cells. Although much has been reported on the evolution of DARC null alleles, little is known about the evolution of the coding portion of this gene or the ...
متن کاملHepatocyte growth factor and hepatocyte growth factor receptor in the lacrimal gland, tears, and cornea.
PURPOSE The purpose of this study was to characterize the expression of hepatocyte growth factor (HGF) and HGF receptor proteins in lacrimal gland, tears, and cornea. METHODS The reverse transcription-polymerase chain reaction method was used to detect HGF and HGF receptor messenger RNA in human lacrimal gland tissue. HGF and HGF (c-met) receptor monoclonal antibody specificity was demonstrat...
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Since its discovery in the late 1980s 1,2, hepatocyte growth factor (HGF) has been under intense investigation for its role in cancer. Hepatocyte growth factor has been established as a mitogen that regulates cell growth and death, a motogen that stimulates cell motility, a morphogen that modulates cell morphology and tissue or organ regeneration, and an angiogenic factor that induces angiogene...
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2015
ISSN: 1740-1526,1740-1534
DOI: 10.1038/nrmicro.2015.16